But as soon as he is established, his kingdom will be broken up and parceled out toward the four winds of heaven. It will not go to his descendants, nor will it have the authority with which he ruled, because his kingdom will be uprooted and given to others.
This language is concise, but there is no ambiguity in the sense. First of all the angel says, After that brave king had stood up, his empire should be broken in pieces: for when Alexander had arrived at his height, he suddenly fell sick, and shortly afterwards died at Babylon. Ambassadors had assembled round him from every quarter. He was quite intoxicated by prosperity, and very probably poisoned himself.
Here, 1. The angel Gabriel lets Daniel know the good service he has done to the Jewish nation (Dan 11:1): "In the first year of Darius the Mede, who destroyed Babylon and released the Jews out of that house of bondage, I stood a strength and fortress to him, that is, I was instrumental to protect him, and give him success in his ward, and...
Commenting on Daniel 11:1-4
And when he shall stand up, his kingdom shall be broken,.... When Alexander was risen up to his highest pitch of grandeur, was sole monarch of the world, in the height of his ambition, in the prime of his days, he was cut off by death; his kingdom remained no more one, but became many, was seized by different persons, his generals, and so broke...