So Cain went out from the presence of the LORD and settled in the land of Nod, east of Eden.
16. And Cain went out from the presence of the Lord . Cain is said to have departed from the presence of God, because, whereas he had hitherto lived in the earth as in an abode belonging to God, now, like an exile removed far from God’s sight, he wanders beyond the limits of His protection.
We have here a further account of Cain, and what became of him after he was rejected of God. I. He tamely submitted to that part of his sentence by which he was hidden from God's face; for (Gen 4:16) he went out from the presence of the Lord, that is, he willingly renounced God and religion, and was content to forego its privileges, so...
Commenting on Genesis 4:16-18
And Cain knew his wife,.... Who this woman was is not certain, nor whether it was his first wife or not; whether his sister, or one that descended from Adam by another of his sons, since this was about the one hundred and thirtieth year of the creation.