And to Seth also a son was born, and he called him Enosh. At that time men began to call upon the name of the LORD.
26. Then began men to call upon the name of the Lord . In the verb ‘to call upon,’ there is a synecdochee , for it embraces generally the whole worship of God. But religion is here properly designated by that which forms its principal part.
This is the first mention of Adam in the story of this chapter. No question, the murder of Abel, and the impenitence and apostasy of Cain, were a very great grief to him and Eve, and the more because their own wickedness did now correct them and their backslidings did reprove them.
Commenting on Genesis 4:25-26
men began to call upon the name of the Lord--rather, by the name of the Lord. God's people, a name probably applied to them in contempt by the world. Next: Genesis Chapter 5