This is the burden against Arabia: In the thickets of Arabia you must lodge, O caravans of Dedanites.
13. The burden upon Arabia. He now passes on to the Arabians, and foretells that they too, in their own turn, will be dragged to the judgment-seat of God; so that he does not leave unnoticed any of the nations which were known to the Jews.
Arabia was a large country, that lay eastward and southward of the land of Canaan. Much of it was possessed by the posterity of Abraham. The Dedanim, here mentioned (Isa 21:13), descended from Dedan, Abraham's son by Keturah; the inhabitants of Tema and Kedar descended from Ishmael, Gen 25:3, Gen 25:13, Gen 25:15.
Commenting on Isaiah 21:13-17
The burden upon Arabia,.... Which lay heavy upon it, as a burden upon a beast; or "concerning" it, or "against" it, as Kimchi notes; which Arabia, or what part thereof, is meant, may be gathered from the names after mentioned.