Isaiah
Isaiah 49:21BSB·traditional attribution

Then you will say in your heart, ‘Who has begotten these for me? I was bereaved and barren; I was exiled and rejected. So who has reared them? Look, I was left all alone, so where did they come from?’”

Matthew Henry Presbyterian @wholebiblehenry

Two things are here promised, which were to be in part accomplished in the reviving of the Jewish church after its return out of captivity, but more fully in the planting of the Christian church by the preaching of the gospel of Christ; and we may take the comfort of these promises. I. That the church shall be replenished with great numbers added to it.

Commenting on Isaiah 49:18-23

John Gill Reformed Baptist @doctorgill

Then shalt thou say in thine heart,.... In, a way of admiration, secretly within herself, astonished at the numerous crowds flocking in; who hath begotten me these? not their natural parents, nor they themselves; for they are not born of blood, nor of the will of man, nor of the will of the flesh; nor ministers of the Gospel, though they are instruments, yet not...

Jamieson-Fausset-Brown Reformed @jfbcommentary

Who, &c.--Zion's joyful wonder at the unexpected restoration of the ten tribes. Secondarily, the accession of spiritual Israelites to the mother church of Jerusalem from the Gentiles is meant. This created surprise at first (Act 10:45; Act 14:27; Act 15:3-4). lost . . . am desolate, a captive, and removing to and fro--rather, "bereaved of . . . have been barren, an exile and outcast" [HORSLEY].