These pairs have befallen you: devastation and destruction, famine and sword. Who will grieve for you? Who can comfort you?
God, having awoke for the comfort of his people, here calls upon them to awake, as afterwards, Isa 52:1. It is a call to awake not so much out of the sleep of sin (though that also is necessary in order to their being ready for deliverance) as out of the stupor of despair.
Commenting on Isaiah 51:17-23
These two things are come unto thee,.... Affliction from the hand of God, though by means of enemies, and no friends to help, support, and comfort, as before hinted: or else this respects what follows, after it is said, who shall be sorry for thee? lament or bemoan thee?
two--classes of evils, for he enumerates four, namely, desolation and destruction to the land and state; famine and the sword to the people. who shall be sorry for thee--so as to give thee effectual relief: as the parallel clause, "By whom shall I comfort thee?" shows (Lam 2:11-13).