Isaiah
Isaiah 53:3BSB·traditional attribution

He was despised and rejected by men, a man of sorrows, acquainted with grief. Like one from whom men hide their faces, He was despised, and we esteemed Him not.

Matthew Henry Presbyterian @wholebiblehenry

The prophet, in the close of the former chapter, had foreseen and foretold the kind reception which the gospel of Christ should find among the Gentiles, that nations and their kings should bid it welcome, that those who had not seen him should believe in him; and though they had not any prophecies among them of gospel grace, which might raise their expectations, and dispose...

Commenting on Isaiah 53:1-3

John Gill Reformed Baptist @doctorgill

He is despised, and rejected of men,.... Or, "ceaseth from men" (f); was not admitted into the company and conversation of men, especially of figure; or ceased from the class of men, in the opinion of others; he was not reckoned among men, was accounted a worm, and no man; or, if a man, yet not in his senses, a madman, nay, one that had...

Jamieson-Fausset-Brown Reformed @jfbcommentary

rejected--"forsaken of men" [GESENIUS]. "Most abject of men." Literally, "He who ceases from men," that is, is no longer regarded as a man [HENGSTENBERG]. (See on Isa 52:14; Isa 49:7). man of sorrows--that is, whose distinguishing characteristic was sorrows. acquainted with--familiar by constant contact with. grief--literally, "disease"; figuratively for all kinds of calamity (Jer 6:14); leprosy especially represented this, being a direct judgment from God.