Pour out Your wrath upon them, and let Your burning anger overtake them.
PSALM 69 There is a close resemblance between this psalm and the twenty-second. In the opening verses, David complains of the barbarous cruelty of his enemies, and of the grievous wrongs which they had inflicted upon him. The particular enemies of whom he speaks are uncertain; some referring the occasion of the composition of the psalm to his persecution by Saul, and others to the rebellion of Absalom.
Commenting on Psalm 69:1-36
Pour out thine indignation upon them. What can be too severe a penalty for those who reject the incarnate God, and refuse to obey the commands of his mercy? They deserve to be flooded with wrath, and they shall be; for upon all who rebel against the Saviour, Christ the Lord, "the wrath is come to the uttermost." 1Th 2:16.
These imprecations are not David's prayers against his enemies, but prophecies of the destruction of Christ's persecutors, especially the Jewish nation, which our Lord himself foretold with tears, and which was accomplished about forty years after the death of Christ.
Commenting on Psalm 69:22-29