For they persecute the one You struck and recount the pain of those You wounded.
PSALM 69 There is a close resemblance between this psalm and the twenty-second. In the opening verses, David complains of the barbarous cruelty of his enemies, and of the grievous wrongs which they had inflicted upon him. The particular enemies of whom he speaks are uncertain; some referring the occasion of the composition of the psalm to his persecution by Saul, and others to the rebellion of Absalom.
Commenting on Psalm 69:1-36
For they persecute him whom thou hast smitten. They are cruel where they should be pitiful. When a stroke comes to any in the providence of God, their friends gather around them and condole, but these wretches hunt the wounded and vex the sick.
These imprecations are not David's prayers against his enemies, but prophecies of the destruction of Christ's persecutors, especially the Jewish nation, which our Lord himself foretold with tears, and which was accomplished about forty years after the death of Christ.
Commenting on Psalm 69:22-29