And the sixth angel poured out his bowl on the great river Euphrates, and its water was dried up to prepare the way for the kings of the East.
The sixth angel poured out his vial; and observe, I. Where it fell - upon the great river Euphrates. Some take it literally, for the place where the Turkish power and empire began; and they think this is a prophecy of the destruction of the Turkish monarchy and of idolatry, which they suppose will be effected about the same time with that of the papacy...
Commenting on Revelation 16:12-16
And I saw three unclean spirits like frogs,.... Rome, the seat of antichrist, being destroyed, and the kingdom of the beast darkened, and brought into great contempt, Mahometanism greatly declining, the Gospel succeeding everywhere, the Jews being converted, and resettled in their own land, the devil bestirs himself more than ordinary; and dispatches his, and the emissaries of antichrist, to the kings of the whole...
Verse 12. And the sixth angel poured out his vial upon the great river Euphrates. On the situation of that river, and the symbolical meaning of this language, . The reference there was supposed to be to the Turkish power, and the analogy of interpretation would seem to require that it should be so understood here.