To Enoch was born Irad, and Irad fathered Mehujael, and Mehujael fathered Methushael, and Methushael fathered Lamech.
We have here a further account of Cain, and what became of him after he was rejected of God. I. He tamely submitted to that part of his sentence by which he was hidden from God's face; for (Gen 4:16) he went out from the presence of the Lord, that is, he willingly renounced God and religion, and was content to forego its privileges, so...
Commenting on Genesis 4:16-18
And Lamech took unto him two wives,.... He was the first we read of that introduced polygamy, contrary to the first institution of marriage, whereby only one man and one woman were to be joined together, and become one flesh, Gen 2:24.
Gen 4:16-24 The family of the Cainites. - Gen 4:16. The geographical situation of the land of Nod, in the front of Eden (קדמת, see Gen 2:14), where Cain settled after his departure from the place or the land of the revealed presence of God (cf. Jon 1:3), cannot be determined.
Commenting on Genesis 4:16-24