John Calvin Reformed @genevareformer

6. And it repented the Lord that he had made man on the earth The repentance which is here ascribed to God does not properly belong to him, but has reference to our understanding of him. For since we cannot comprehend him as he is, it is necessary that, for our sakes he should, in a certain sense, transform himself.

Matthew Henry Presbyterian @wholebiblehenry

Here is, I. God's resentment of man's wickedness. He did not see it as an unconcerned spectator, but as one injured and affronted by it; he saw it as a tender father sees the folly and stubbornness of a rebellious and disobedient child, which not only angers him, but grieves him, and makes him wish he had been written childless.

Commenting on Genesis 6:6-7

John Gill Reformed Baptist @doctorgill

And it repented the Lord that he had made man on the earth,.... Because of the wickedness of man, the wickedness of his heart, and the wickedness of his life and conversation, which was so general, and increased to such a degree, that it was intolerable; wherefore God could have wished, as it were, that he had never made him, since he proved so bad...