Manasseh devours Ephraim, and Ephraim devours Manasseh; together they are against Judah. For all this his anger has not turned away, and his hand is stretched out still.
21. Manasseh, Ephraim. These tribes were closely related to each other; for besides their being descended from the same ancestor, Abraham, a close relationship arose out of their being descended from one patriarch, his grandson, Joseph. (Genesis 41:50-52.) But though they were closely allied, still God threatens that he will cause them to destroy themselves by mutual conflict, as if they were devouring the flesh...
Here are terrible threatenings, which are directed primarily against Israel, the kingdom of the ten tribes, Ephraim and Samaria, the ruin of which is here foretold, with all the woeful confusions that were the prefaces to that ruin, all which came to pass within a few years after; but they look further, to all the enemies of the throne and kingdom of Christ the Son...
Commenting on Isaiah 9:8-21
Manasseh, Ephraim; and Ephraim, Manasseh,.... That is, "Manasseh" shall eat or devour "Ephraim"; and "Ephraim" shall eat or devour "Manasseh"; as the Septuagint, Syriac, and Arabic versions render it; which is to be understood of their quarrels, contentions, and wars among themselves, whereby they bit, devoured, and consumed each other, though they were brethren; which explains and confirms what is before said, of no man...