Matthew
Matthew 20:22ESV·traditional attribution

Jesus answered, “You do not know what you are asking. Are you able to drink the cup that I am to drink?” They said to him, “We are able.”

John Calvin Reformed @genevareformer

22. You know not what you ask. Their ignorance was worthy of blame on two accounts; first, because their ambition led them to desire more than was proper; and, secondly, because, instead of the heavenly kingdom of Christ, they had formed the idea of a phantom in the air.

John Gill Reformed Baptist @doctorgill

And he saith unto them, ye shall drink indeed of my cup,.... Not of the selfsame, but of what was like unto it; meaning, that they should endure much persecution for his name's sake, as all that will live godly in Christ Jesus must expect in one shape or another.

Albert Barnes Presbyterian @notesbybarnes

Verse 22. Ye know not what ye ask. You do not know the nature of your request, nor what would be involved in it. You suppose that it would be attended only with honour and happiness if the request was granted; whereas, it would require much suffering and trial. Are ye able to drink of the cup, etc.