In the end it bites like a serpent and stings like an adder.
Solomon here gives fair warning against the sin of drunkenness, to confirm what he had said, Pro 23:20. I. He cautions all people to keep out of the way of temptations to this sin (Pro 23:31): Look not thou upon the wine when it is red. Red wine was in Canaan looked upon as the best wine, it is therefore called the blood of the grape.
Commenting on Proverbs 23:29-35
At the last it biteth like a serpent,.... Though it goes down sweetly, yet it leaves a sting behind it, intemperately drank; a nausea in the stomach, a stink in the breath, pains and giddiness in the head, weakness in the eyes, trembling in the members of the body, palsy, gout, and other distempers, very painful and grievous to be bore; and, what is worse...
The acute miseries resulting from drunkenness contrasted with the temptations.