May their camp be a desolation; let no one dwell in their tents.
PSALM 69 There is a close resemblance between this psalm and the twenty-second. In the opening verses, David complains of the barbarous cruelty of his enemies, and of the grievous wrongs which they had inflicted upon him. The particular enemies of whom he speaks are uncertain; some referring the occasion of the composition of the psalm to his persecution by Saul, and others to the rebellion of Absalom.
Commenting on Psalm 69:1-36
Let their habitation be desolate; and let none dwell in their tents. This may signify that their posterity shall be cut off, and the abode which they occupy shall be left a ruin; or, as our Lord quoted it, it refers to the temple, which was left by its divine occupant and became a desolation.
These imprecations are not David's prayers against his enemies, but prophecies of the destruction of Christ's persecutors, especially the Jewish nation, which our Lord himself foretold with tears, and which was accomplished about forty years after the death of Christ.
Commenting on Psalm 69:22-29